SPLICING REPORTER MICE REVEALED THE EVOLUTIONALLY CONSERVED SWITCHING MECHANISM OF TISSUE-SPECIFIC ALTERNATIVE EXON SELECTION.

Splicing reporter mice revealed the evolutionally conserved switching mechanism of tissue-specific alternative exon selection.

Since alternative splicing of pre-mRNAs is essential for generating tissue-specific diversity in proteome, elucidating its regulatory mechanism is indispensable to understand developmental process or tissue-specific functions.We have been focusing on tissue-specific regulation of mutually exclusive selection of alternative exons because this implie

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pH-Sensitive Mixed Micelles Assembled from PDEAEMA-PPEGMA and PCL-PPEGMA for Doxorubicin Delivery: Experimental and DPD Simulations Study

To decrease critical micelle concentration (CMC), improve stability, folk rivet sweat and keep high drug-loading capacity, three pH-sensitive mixed micelles applied for anticancer drug controlled delivery were prepared by the mixture of polymers poly (N,N-diethylaminoethyl methacrylate)-b-poly(poly(ethylene glycol) methyl ether methacrylate) (PDEAE

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